Define the following as related to proteins (i) Peptide linkage (ii) Primary structure (iii) Denaturation.
Answers
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PEPTIDE LINKAGE
The linkage of (C=O)-N-H by which the amino acids gets attached.
PRIMARY ALCOHOL
Each polypeptide in a protein molecule having amino acids which are linked with each other in a specific sequence.
DENATURATION
When a protein in subjected to physical change like change in temperature or chemical change like change in pH, protein loses in biological activity.
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(i) Peptide linkage
The amide formed between -COOH group of one molecule of an amino acid and -NH2 group of another molecule of the amino acid by the elimination of a water molecule is called a peptide linkage.
(ii) Primary structure
The primary structure of protein refers to the specific sequence in which various amino acids are present in it, i.e., the sequence of linkages between amino acids in a polypeptide chain. The sequence in which amino acids are arranged is different in each protein. A change in the sequence creates a different protein.
(iii) Denaturation
In a biological system, a protein is found to have a unique 3-dimensional structure and a unique biological activity. In such a situation, the protein is called native protein. However, when the native protein is subjected to physical changes such as change in temperature or chemical changes such as change in pH, its H-bonds are disturbed. This disturbance unfolds the globules and uncoil the helix. As a result, the protein loses its biological activity. This loss of biological activity by the protein is called denaturation. During denaturation, the secondary and the tertiary structures of the protein get destroyed, but the primary structure remains unaltered.
One of the examples of denaturation of proteins is the coagulation of egg white when an egg is boiled.
