Question

describe the methods for the separation of macromolecules based on their molecular size and solubility.

Answer 1

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These are the techniques to separate macro-molecules on the basis of:

●Molecular size: Gel filtration Chromatography, Centrifugation, Gel Electrophoresis using SDS is the technique to separate macro-molecules on the basis of molecular size.

● Solubility: on the basis of solubility, salting out technique can be used

●Molecular affinity: Affinity chromatography is used to separate molecules on the basis of their molecular affinity.