Effect of gel properties on transdermal iontophoretic delivery of diclofenac sodium
Answers
Answered by
2
hydrogels were found to possess adequate conductivity at pH 7.4 to enable iontophoretic delivery of DS. In vitro studies indicated that passive transport of DS across porcine skin from hydrogels was comparable (p>0.05) to aqueous solution. The lead hydrogel (F1), containing geraniol was found to enhance the iontophoretic flux of DS by 5.16 fold at 1.5 V compared to passive control. In vivostudies in rats indicated that CVI on application of F1significantly suppressed (p<0.001) carrageenan induced edema compared to passive treatment throughout the study.
Similar questions