Endothelium derived relaxing factors (EDRF) induced vasodilation is mediated by
A) Increased intracellular cGMP.
B) Decreased intracellular cGMP.
C) Increased extracellular cAMP.
D) Decreased intracellular cAMP.
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i think answer is c ... increased extracellular cAMP
SpectreHunter:
Okay. Can someone give me an idea why so?
pls cler msg
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I mean, how does extracellular cAMP mediate EDRF induced vasodilation?
cAMP is a second messenger, used for intracellular signal transduction, such as transferring into cells the effects of hormones like glucagon and adrenaline, which cannot pass through the plasma membrane. It is also involved in the activation of protein kinases.
Hmm..........
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Well, cAMP is a second messenger inside the cytoplasm. So, I don't think that a change in extracellular concentration matters. Does it?
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