Generation of combination diversity among immunoglobulin involves
1) mRNA splicing
2)DNA rearrangement
3) switch sites
4) recombination signals sequence.
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Antibody diversity is generated in four main ways. ... The third is due to the different possible combinations of a heavy and a light chain in the complete immunoglobulin molecule. The fourth is a mutational process that occurs in mature B cells, acting only on rearranged DNA encoding the V regions
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