Question

Gracile neurons contribute to the maintenance of neuropathic pain in peripheral and central neuropathic models. J neurotrauma

Answer 1

Gracile neurons contribute to the maintenance of neuropathic pain in peripheral and central neuropathic models. J neurotrauma. These results may imply that pathophysiological changes in the spinal level following partial sciatic nerve injury are more associated with thermal hyperalgesia, while those in supraspinal level are associated with mechanical allodynia in addition to thermal hyperalgesia. This speculation is partially supported by the previous studies reporting that ascending input to nucleus gracilis is critical to the manifestation of tactile allodynia [43][44][45]. Therefore, it is possible that histamine may inhibit both mechanical allodynia and thermal hyperalgesia of CRPS-2 through acting on H 1 receptors at the supraspinal levels. ...