Growth factors regulate cell cycle via
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Elements of the cell cycle program that are regulated by signaling enzymes. Growth factors promote phosphorylation of Rb by regulating the activity of the G1 Cdks. This involves promoting the synthesis and stability of cyclin subunits, as well as decreasing the levels of Cdk inhibitors (Fig. 2B).
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Elements of the cell cycle program that are regulated by signaling enzymes. Growth factors promote phosphorylation of Rb by regulating the activity of the G1 Cdks. This involves promoting the synthesis and stability of cyclin subunits, as well as decreasing the levels of Cdk inhibitors (Fig. 2B).
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