Question

How creatinine is formed by the breakdown of creatine?

Answer 1

Creatinine is a break-down product of creatine phosphate in muscle tissue. It is usually produced at a fairly constant rate. Creatinine is cleared by the kidneys with minimal tubular reabsorption. Creatinine accumulates in the blood when GFR decreases in the setting of renal dysfunction.

Answer 2

Answer:

creatinine is a non protein nitrogenous compound that is produced by the breakdown of creatine in muscle creatine is found in serum, plasma and urine and is excreted by glomerular filtration at the constant rate and in the same concentration as in plasma