In Drosophila (fruit flies), cut wings are controlled by a recessive X – linked allele (ct), and fuzzy body is controlled by a recessive autosomal allele (fy). When a fuzzy female is mated with a cut male, all the members of the F1 generation are wildtype. What are the genotypic and phenotypic ratios of the F2 by sex?
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Open access peer-reviewed chapter
The Fruit Fly, Drosophila melanogaster: The Making of a Model (Part I)
By Mariateresa Allocca, Sheri Zola and Paola Bellosta
Submitted: August 5th 2017Reviewed: November 30th 2017Published: February 13th 2018
DOI: 10.5772/intechopen.72832
Home > Books > Drosophila melanogaster - Model for Recent Advances in Genetics and Therapeutics
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Abstract
The fruit fly, Drosophila melanogaster (Meigen, 1830) has been established as a cornerstone for research into a wide array of subjects including diseases, development, physiology, and genetics. Thanks to an abundance of genetic tools, publicly available fly stocks, and databases, as well as their considerable biological similarity to mammalian systems, Drosophila has been solidified as a key model organism for elucidating many aspects of human disease. Herein is presented an overview of what makes Drosophila such an appealing model organism. In Part I of this chapter, basic Drosophila biology is reviewed and the most relevant genetic tools available to Drosophila researchers are covered. Then in part II, we outline the use of Drosophila as a model organism to study a wide array of pathologies in which Drosophila has been used, along with key advances made in the specific field using the fly as a model organism.