Insulin signal transduction in human skeletal muscle: identifying the defects in type ii diabetes.
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Insulin signal transduction in human skeletal muscle: identifying the defects in type ii diabetes.
In patients with type 2 diabetes, defects in insulin-stimulated glucose metabolism in skeletal muscle have been attributed to impaired glucose transport (7,8), glycogen synthesis (9), and glycogen synthase activation (10). These defects may result from impaired insulin signal transduction (11).
In patients with type 2 diabetes, defects in insulin-stimulated glucose metabolism in skeletal muscle have been attributed to impaired glucose transport (7,8), glycogen synthesis (9), and glycogen synthase activation (10). These defects may result from impaired insulin signal transduction (11). The molecular signaling mechanisms by which insulin regulates glucose uptake and storage is initiated by the binding of insulin to its specific cell-surface receptor, which results in receptor autophosphorylation and activation of insulin receptor tyrosine kinase (IRTK).