Question

It is not necessary that the pathogens affect the organ or tissue depending on point of entry... Explain

Answer 1

This statement means that it is not necessary that, if  the pathogen enters the body by different ways, it alters the site and consequence of infection
Example:

(a) AIDS causing virus-enter through sex organs - spread to lymph modes all over the body.
(b) Japanese encephalitis - virus - enter blood through mosquito bite - reaches brain.
© Malaria- protozoa plasmodium- enter blood through mosquito bite - reaches liver and then passes into the RBC.