Question

Many different types of mutations can occur within the body. Cystic fibrosis is a genetic disorder that is caused by different mutations within the CFTR gene. One mutation in the CFTR gene that leads to cystic fibrosis causes translation to end earlier in the gene sequence. Which type of mutation causes this translation error that leads to cystic fibrosis? silent missense nonsense deletion

Answer 1

Answer:

Explanation:CF is caused by a mutation in the gene cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation, ΔF508, is a deletion (Δ signifying deletion) of three nucleotides that results in a loss of the amino acid phenylalanine (F) at the 508th position on the protein.

Answer 2

A nonsense mutation is a correct answer.

• A nonsense mutation is a mutation that causes the termination of coding. The proteins formed are shortened and also non-functional.
• Missense mutation changes the code of protein. The change occurs by the replacement of a single nucleotide which changes the amino acid.
• Silent mutation does not affect the sequence of genes. Hence, the proteins formed are not different.
• Deletion mutation refers to the loss of nucleotide in the gene, which can be single or multiple.

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