Mention the types of cell that form the cellular barriers of innate immunity
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Leukocytes (WBC) and natural killer in the blood are two types of cells that act as 'cellular barriers' to provide innate immunity in humans.
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Neutrophils contain granules that has toxic substances which inhibit the growth of pathogens. These are often the first defence cells that reach the site of infection. These attack pathogens by initiating a process called respiratory burst during which strong oxidising agents such as hydrogen peroxide, hypochlorite and so on are produced. This is how neutrophils form a barrier against pathogens.
Innate immunity − It is present from the time of birth. It is non-specific. It consists of 4 kinds of barriers.
Physical barriers − Skin and mucus coating of respiratory, gastrointestinal, and urogenital tract prevent entry of microbes into body.
Physiological barriers − Acid in stomach, saliva in mouth, tears from eyes
Cellular barriers − Blood has leukocytes such as polymorpho nuclear leukocytes, monocytes, etc. and tissue has macrophages which phagocytose the microbes.
Cytokine barriers − Special proteins called interferons are secreted by virus-infected cells that prevent the further spread of viral infection.
Innate immunity − It is present from the time of birth. It is non-specific. It consists of 4 kinds of barriers.
Physical barriers − Skin and mucus coating of respiratory, gastrointestinal, and urogenital tract prevent entry of microbes into body.
Physiological barriers − Acid in stomach, saliva in mouth, tears from eyes
Cellular barriers − Blood has leukocytes such as polymorpho nuclear leukocytes, monocytes, etc. and tissue has macrophages which phagocytose the microbes.
Cytokine barriers − Special proteins called interferons are secreted by virus-infected cells that prevent the further spread of viral infection.
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