Significance of complexation effficiency in cyclodextrin complexation
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Complexation with cyclodextrin (CD) is known as an effective method for enhancing dissolution properties and bioavailability of poorly soluble drugs. CDs are capable of forming inclusion complexes with many drugs by including a whole drug molecule or only some nonpolar part of it inside their cavity.
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A complexation efficiency of 0.1 suggests that one out of 11 cyclodextrin molecules forms a complex with the drug. If the complexation efficiency is 0.01, then only one out of 100 cyclodextrin molecules forms a complex.
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