State the characteristics of streptomycin.
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Streptomycin is an antibiotic used to treat a number of bacterial infections. This includes tuberculosis, Mycobacterium aviumcomplex, endocarditis, brucellosis, Burkholderia infection, plague, tularemia, and rat bite fever. For active tuberculosis it is often given together with isoniazid, rifampicin, and pyrazinamide. It is given by injection into a vein or muscle.
Abstract
Some regularities of distribution and binding of streptomycin in the blood, organs and tissues of immunized rabbits werer studied. The leveles of the bound and free antibiotic in ther were determined. It was found that the immunobiological state of the rabbits had a definite effect on the distribution character and binding of streptomycin with proteins and cells in the animal organs and tissues. These changes were most pronounced in the organs and tissues of lymphoid and hematopoietic systems, the cells of which are indirect active participants of the immunity formation. As a result of proliferation of these cells the antibiotic was accumulated in higher amounts and bound more actively especially in the thymus gland and bone marrow, the central organs of the immunological reconstruction of the host. The studies are indicative of the presence of interaction between immunogenesis, distribution and binding of streptomycin in immunized animals.
Abstract
Some regularities of distribution and binding of streptomycin in the blood, organs and tissues of immunized rabbits werer studied. The leveles of the bound and free antibiotic in ther were determined. It was found that the immunobiological state of the rabbits had a definite effect on the distribution character and binding of streptomycin with proteins and cells in the animal organs and tissues. These changes were most pronounced in the organs and tissues of lymphoid and hematopoietic systems, the cells of which are indirect active participants of the immunity formation. As a result of proliferation of these cells the antibiotic was accumulated in higher amounts and bound more actively especially in the thymus gland and bone marrow, the central organs of the immunological reconstruction of the host. The studies are indicative of the presence of interaction between immunogenesis, distribution and binding of streptomycin in immunized animals.
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Streptomycin; 57-92-1; Streptomycin A; Gerox; Streptomycin sulphate; Estreptomicina More...Streptomycin is an antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.PubChem CID: 19649Chemical Names: Streptomycin; 57-92-1; Stre...Molecular Formula: C21H39N7O12Molecular Weight: 581.58 g/mol
Streptomycin; 57-92-1; Streptomycin A; Gerox; Streptomycin sulphate; Estreptomicina More...Streptomycin is an antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.PubChem CID: 19649Chemical Names: Streptomycin; 57-92-1; Stre...Molecular Formula: C21H39N7O12Molecular Weight: 581.58 g/mol
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