What is G0 phase in cell cycle?which cells usually enter this phase?is this phase metabolically active?support your answer by appropriate reasons.
Answers
The G0 phase, or 'resting phase' is a period in the cell cycle in which cells exist in an inactive, non-cycling state. The mammalian cell division cycle is controlled with extreme precision to complete the duplication of the genome and the segregation of replicated chromosome to daughter cells.[1] In the past, cells were thought to enter G0 by default simply because of proliferation limits such as nutrient deprivation or contact inhibition. G0 is now viewed as a way for cells to preserve important functions over a long period.
G0 was first suggested as a cell state based on early cell cycle studies. When the first studies defined the four phases of the cell cycle using radioactive labeling techniques, it was discovered that not all cells in a population proliferate at similar rates.A population’s “growth fraction” – or the fraction of the population that was growing – was actively proliferating, but other cells existed in a non-proliferative state. Some of these non-proliferating cells could respond to extrinsic stimuli and proliferate by re-entering the cell cycle.