Question

what is limit of determination and limit of quantification????
in Analytical method validation ​

Answer 1

The limit of quantification (LOQ) by showing the probability density function for normally distributed measurements at the blank, at the LOD defined as 3 * standard deviation of the blank, and at the LOQ defined as 10 * standard deviation of the blanky. In analytical chemistry, the detection limit, lower limit of detection, or LOD (limit of detection), is the lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%).