Question

What is the difference between a negative gene regulation and a positive gene regulation?

Answer 1

In negative gene regulation a repressor protein binds to an operator to prevent a gene from being expressed. In positive gene regulation a transcription factor is required to bind at the promoter in order to enable RNA polymerase to initiate transcription.

Answer 2

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When a gene is subject to positive transcriptional control, the binding of a specific transcription factor to the regulatory element promotes transcription. When a gene is subject to negative transcriptional control, the binding of a specific transcription factor to a regulator elements represses transcription.