What was Marshall Nirenberg and Heinrich Matthaei’s contribution to our current understanding of the genetic code? discovery of codons discovery and extraction of DNA creation of a model of DNA creation of Photo 51
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The correct answer is discovery of codons.
Marshall Nirenberg and Heinrich Matthaei experimentally deciphered the first out of 64 codons present in our biological system.
They were successful in performing the translation in a cell-free system.
They extracted all the essential elements required for translation from E.coli in a test tube and added synthetic RNA which consisted of only uracil nucleotide (poly-U RNA).
The protein extracted after the experiment was poly phenylalanine. So, it helped in decoding the first codon out of 64 i.e. UUU codes for phenylalanine.
Later, other codons were also decoded with a similar approach.
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A. discovery of codons.
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