Question

Why are some antibiotics detrimental to human mitochondria?

Answer 1

because it makes sense that antibiotics could have adverse effects on human cells. After all, antibiotics have side effects within the human body. Given that biochemical processes take place at the cellular level, and since antibiotics disrupt bacterial cell walls or inhibit the bacteria’s ability to replicate by interrupting protein synthesis, it seems logical that these would be interrelated.

In doing a bit of research, I found a couple of scholarly articles that might be helpful to you in answering this question. Indeed, it's been found that the oxazolidinones, B-lactams, quinolones and aminoglycosides have detrimental effects on mammalian mitochondria. These affects have been found to have a direct link to the side effects associated with these classes of antibiotics.