Question

How can phenol be converted to aspirin?

Answer 1

By kolbe Reaction
first prepare salicyclic acid

and then acetylation of salicylic acid gives aspirin

Answer 2

Reaction of phenol with NaOH and CO2 (Kolbe–Schmitt reaction), then with H2SO4 gives salicylic acid.



Phenol Salicylic acid

On Addition of Acetic anhydride to salicylic acid turn the hydroxyl group into an ester giving Asprin.



Salicylic acid Acetic acetic acid Asprin(acetyl Salicylic acid)

anhydride

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