How phosphatedyl serine comes in the outer side when cells undeego apoptosis?
Answers
Phosphatidylserine (abbreviated Ptd-L-Ser or PS) is a phospholipid and is a component of the cell membrane. It plays a key role in cell cycle signaling, specifically in relation to apoptosis. It is a key pathway for viruses to enter cells via viral apoptotic mimicry.[citation needed]
Phosphatidylserine
Components of phosphatidylserines:
Blue, green: variable fatty acid groups
Black: glycerol
Red: phosphate
Purple: serine
Phosphatidyl serin, phospholipid with a negative charge headgroup, is an important component of the eukaryotic cellular membrane. On the plasma membrane, instead of being distributed evenly, phosphatidyl serin is preferentially found in the inner palm. Interference in this asymmetry, which is the presence of phosphatidyl serin on the surface of the cell, is known to play a central role in both apoptosis and blood clots. Regardless of its importance, relatively few cells are known about phosphatidyl serin: its precise sub-cellular localization, transmembrane topology and intracellular mobility are poorly characterized. Recent development of new, genetic-encoded investigations capable of detect phosphatidyl serin within live cells, however, is leading to understanding this phospholipid's biology depth. The purpose of this review is to give an overview of current methods for detecting phosphatidyl syringe within the cells, and some recent receipts obtained from their use.
Phosphatidyl serin (PS) is a glycerophospholipid that is present in the membrane of all eukaryotic cells. Like the majority of glycerofophilipides, PS has a glycerol spinal cord that is surrounded by Glycerol Mori's Sn-2 carbon and variable length and 2 fatty acids of saturation and phosphate group on snap 3. The specific feature of PS is the attachment of a serin to phosphate; As a result the combined headgroup gives pure negative charge to the PS. In mammalian cells, PS is produced by exchange of phosphatidyl coiline (PC) or phosphatidyl ethanolmine (PE) head-group exchange for syringe by enzymes PS-synthase 1 (PSS 1) and PSS 2, respectively. Both enzymes are found in the membrane associated with mitochondrial (MAM), special areas of endoplasmic reticulum (ER) which are tightly applied and co-isolated with mitochondria. From the MAM, the PS travels to other membranes within the cell.